Solvent Free Multi-component Synthesis of Amidoalkylnaphthols Using Phenylphosphinic Acid as an Organocatalyst

Document Type : Research paper


Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran


One pot solvent less synthesis of amidoalkylnaphthol derivatives via reaction of aldehydes, 2-naphthol and acetamide/urea in the presence of phenylphosphinic acid is  described. This methodology provides a simple synthetic route to amidoalkylnaphthols in good to high yields.